	Robin Gutell Associate Professor, Section of Integrative Biology see also: Institute for Cellular and Molecular Biology The Center for Computational Biology and Bioinformatics Interpreting Biological Sequences
Lab web page	Education \| Research Interests \| Instruction \| Grad Programs \| Publications
E-mail: robin.gutell@mail.utexas.edu Office: PAT 141MB, (512) 232-4814 Lab: (512) 232-4815 Fax: (512) 471-3878	Education B.A., Biology, University of California, San Diego, 1977, magna cum laude. Ph.D., Molecular Biology, University of California, Santa Cruz, 1984. postdoctoral fellow, University of Illinois, Urbana, 1985-1987. Research Interests The analysis of RNA sequences from an RNA structure and a molecular phylogenetic perspective can reveal the secondary and tertiary structure of RNA molecules, most notably for the 16S and 23S ribosomal RNAs, and phylogenetic relationships for organisms that span the entire tree of life. We utilize computational biology and bioinformatics to study: RNA secondary and tertiary structure prediction with comparative sequence analysis; RNA motifs: relationships between RNA sequences and their higher-order structures; RNA folding: transforming a single RNA sequence into its biologically correct higher-order structure; RNA structure-based phylogenetic analysis; and Comparative RNA Web site: RNA sequence/structure knowledge base. More information - see Dr. Gutell lab's Comparative RNA Web (CRW) Site. Instruction Fall & Spring Class Schedule Associated Graduate Programs Cell and Molecular Biology bioinformatics & computational biology molecular genetics structural biology Biomedical Engineering Computational and Applied Mathematics Publications Below is a brief list of recent publications of Dr. Gutell. Visit the Gutell Lab Web Pages for a full interactive list of his publications. Click on article title for Medline abstract (where available). 104. Smith T.F., Gutell R., Lee J., and Hartman H. (2008). The origin and evolution of the ribosome. Biology Direct, 3:16. 103. Chandramouli P., Topf M., Ménétret J.-F., Eswar N., Cannone J.J., Gutell R.R., Sali A., and Akey C.W. (2008). Structure of the Mammalian 80S Ribosome at 8.7 Å Resolution. Structure, 16:535-548. 102. Wang S., Gutell R.R., and Miranker D.P. (2007). Biclustering as a Method for RNA Local Multiple Sequence Alignment. Bioinformatics, 23:3289-3296. 101. Lee C.-Y., Lee J.C., and Gutell R.R. (2007). Networks of interactions in the secondary and tertiary structure of ribosomal RNA. Physica A, 386:564-572. 100. Gillespie J.J., Johnston J.S., Cannone J.J., and Gutell R.R. (2006). Characteristics of the nuclear (18S, 5.8S, 28S and 5S) and mitochondrial (12S and 16S) rRNA genes of Apis mellifera (Insecta:Hymenoptera): structure, organization, and retrotransposable elements. Insect Molecular Biology, 15:657-686. 99. Weinstock et al. (81 authors), Gillespie J.J., Cannone J.J., Gutell R.R., et al. (100 authors) (2006). Insights into social insects from the genome of the honey bee Apis mellifera. Nature, 443:931-949. 98. Lee J.C., Gutell R.R., and Russell R. (2006). The UAA/GAN internal loop motif: a new RNA structural element that forms a cross-strand AAA stack and long-range tertiary interactions. Journal of Molecular Biology, 360:978-988. 97. Alverson A.J., Cannone J., Gutell R.R., and Theriot E.C. (2006). The Evolution of Elongate Shape in Diatoms. Journal of Phycology, 42:655-668. 93. Müller K.M., Ellenor D.W., Sherwood A.R., Sheath R.G., Cannone J.J., and Gutell R.R. (2005). Evidence for Lateral Transfer of an IE Intron Between Fungal and Red Algal Small Subunit rRNA Genes. Journal of Phycology, 41:380-390. 92. Lee J.C. and Gutell R.R. (2004). Diversity of Base-pair Conformations and their Occurrence in rRNA Structure and RNA Structural Motifs. Journal of Molecular Biology, 344:1225-1249. 90. Doshi K.J., Cannone J.J., Cobaugh C.W., and Gutell R.R. (2004). Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction. BioMed Central Bioinformatics, 5:105. 85. Lee J.C., Cannone J.J., and Gutell R.R. (2003). The Lonepair Triloop: A New Motif in RNA Structure. Journal of Molecular Biology, 325:65-83. 81. Gutell R.R., Lee J.C., and Cannone J.J. (2002). The Accuracy of Ribosomal RNA Comparative Structure Models. Current Opinion in Structural Biology, 12:301-310. 80. Cannone J.J, Subramanian S., Schnare M.N., Collett J.R., D'Souza L.M., Du Y., Feng B., Lin N., Madabusi L.V., Müller K.M., Pande N., Shang Z., Yu N., and Gutell R.R. (2002). The Comparative RNA Web (CRW) Site: An Online Database of Comparative Sequence and Structure Information for Ribosomal, Intron, and Other RNAs. BioMed Central Bioinformatics. 3:2. [Correction: BioMed Central Bioinformatics. 3:15.] 75. Elgavish T., Cannone J.J., Lee J.C., Harvey S.C., and Gutell R.R. (2001). AA.AG@Helix.Ends: A:A and A:G Base-pairs at the Ends of 16 S and 23 S rRNA Helices. Journal of Molecular Biology. 310:735-753. 74. Gutell R.R., Cannone J.J., Shang Z., Du Y., and Serra M.J. (2000). A Story: Unpaired Adenosine Bases in Ribosomal RNA. Journal of Molecular Biology. 304:335-354.

Robin Gutell

Associate Professor, Section of Integrative Biology
see also:
Institute for Cellular and Molecular Biology
The Center for Computational Biology and Bioinformatics
Interpreting Biological Sequences

Lab web page

Education | Research Interests | Instruction | Grad Programs | Publications

E-mail:
robin.gutell@mail.utexas.edu
Office:
PAT 141MB,
(512) 232-4814
Lab:
(512) 232-4815
Fax:
(512) 471-3878

Education

B.A., Biology, University of California, San Diego, 1977, magna cum laude.
Ph.D., Molecular Biology, University of California, Santa Cruz, 1984.
postdoctoral fellow, University of Illinois, Urbana, 1985-1987.

Research Interests

The analysis of RNA sequences from an RNA structure and a molecular phylogenetic perspective can reveal the secondary and tertiary structure of RNA molecules, most notably for the 16S and 23S ribosomal RNAs, and phylogenetic relationships for organisms that span the entire tree of life. We utilize computational biology and bioinformatics to study:

RNA secondary and tertiary structure prediction with comparative sequence analysis;
RNA motifs: relationships between RNA sequences and their higher-order structures;
RNA folding: transforming a single RNA sequence into its biologically correct higher-order structure;
RNA structure-based phylogenetic analysis; and
Comparative RNA Web site: RNA sequence/structure knowledge base.

More information - see Dr. Gutell lab's Comparative RNA Web (CRW) Site.

Instruction

Fall & Spring Class Schedule

Associated Graduate Programs

Publications

Below is a brief list of recent publications of Dr. Gutell. Visit the Gutell Lab Web Pages for a full interactive list of his publications. Click on article title for Medline abstract (where available).

104. Smith T.F., Gutell R., Lee J., and Hartman H. (2008). The origin and evolution of the ribosome. Biology Direct, 3:16.
103. Chandramouli P., Topf M., Ménétret J.-F., Eswar N., Cannone J.J., Gutell R.R., Sali A., and Akey C.W. (2008). Structure of the Mammalian 80S Ribosome at 8.7 Å Resolution. Structure, 16:535-548.
102. Wang S., Gutell R.R., and Miranker D.P. (2007). Biclustering as a Method for RNA Local Multiple Sequence Alignment. Bioinformatics, 23:3289-3296.
101. Lee C.-Y., Lee J.C., and Gutell R.R. (2007). Networks of interactions in the secondary and tertiary structure of ribosomal RNA. Physica A, 386:564-572.
100. Gillespie J.J., Johnston J.S., Cannone J.J., and Gutell R.R. (2006). Characteristics of the nuclear (18S, 5.8S, 28S and 5S) and mitochondrial (12S and 16S) rRNA genes of Apis mellifera (Insecta:Hymenoptera): structure, organization, and retrotransposable elements. Insect Molecular Biology, 15:657-686.
99. Weinstock et al. (81 authors), Gillespie J.J., Cannone J.J., Gutell R.R., et al. (100 authors) (2006). Insights into social insects from the genome of the honey bee Apis mellifera. Nature, 443:931-949.
98. Lee J.C., Gutell R.R., and Russell R. (2006). The UAA/GAN internal loop motif: a new RNA structural element that forms a cross-strand AAA stack and long-range tertiary interactions. Journal of Molecular Biology, 360:978-988.
97. Alverson A.J., Cannone J., Gutell R.R., and Theriot E.C. (2006). The Evolution of Elongate Shape in Diatoms. Journal of Phycology, 42:655-668.
93. Müller K.M., Ellenor D.W., Sherwood A.R., Sheath R.G., Cannone J.J., and Gutell R.R. (2005). Evidence for Lateral Transfer of an IE Intron Between Fungal and Red Algal Small Subunit rRNA Genes. Journal of Phycology, 41:380-390.
92. Lee J.C. and Gutell R.R. (2004). Diversity of Base-pair Conformations and their Occurrence in rRNA Structure and RNA Structural Motifs. Journal of Molecular Biology, 344:1225-1249.
90. Doshi K.J., Cannone J.J., Cobaugh C.W., and Gutell R.R. (2004). Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction. BioMed Central Bioinformatics, 5:105.
85. Lee J.C., Cannone J.J., and Gutell R.R. (2003). The Lonepair Triloop: A New Motif in RNA Structure. Journal of Molecular Biology, 325:65-83.
81. Gutell R.R., Lee J.C., and Cannone J.J. (2002). The Accuracy of Ribosomal RNA Comparative Structure Models. Current Opinion in Structural Biology, 12:301-310.
80. Cannone J.J, Subramanian S., Schnare M.N., Collett J.R., D'Souza L.M., Du Y., Feng B., Lin N., Madabusi L.V., Müller K.M., Pande N., Shang Z., Yu N., and Gutell R.R. (2002). The Comparative RNA Web (CRW) Site: An Online Database of Comparative Sequence and Structure Information for Ribosomal, Intron, and Other RNAs. BioMed Central Bioinformatics. 3:2. [Correction: BioMed Central Bioinformatics. 3:15.]
75. Elgavish T., Cannone J.J., Lee J.C., Harvey S.C., and Gutell R.R. (2001). AA.AG@Helix.Ends: A:A and A:G Base-pairs at the Ends of 16 S and 23 S rRNA Helices. Journal of Molecular Biology. 310:735-753.
74. Gutell R.R., Cannone J.J., Shang Z., Du Y., and Serra M.J. (2000). A Story: Unpaired Adenosine Bases in Ribosomal RNA. Journal of Molecular Biology. 304:335-354.