(512) 471-6028 (office)
(512) 471-5413 (lab)
- Oct. 1996 Diplom (equiv. to Master's degree) in physics, Ruhr-Universitat Bochum
- June 1999 Ph.D. in physics, Ruhr-Universitat Bochum
I am a computational biologist. I use bioinformatical and statistical methods to analyze biological data sets, in particular whole-genome and high-throughput data sets; I also develop mathematical models and computer simulations of biological systems. While my lab does not perform any experiments, I have extensive collaborations with experimental groups and I frequently co-advise students whose research has an experimental component.
My current research covers three broad but interconnected areas: 1. biophysical mechanisms of molecular evolution; 2. microbial adaptation and experimental evolution; 3. disease dynamics. A recurring theme in my research is evolution; modern biomedical research is deeply connected to evolutionary biology.
1. One of my main research goals is to develop mechanistic, biophysical explanations for patterns of molecular evolution observable in extant genomes. Many of the patterns that we detect reflect fundamental biophysical mechanisms operating in all cellular life forms. My research in this area has led to the hypothesis that selection against protein misfolding is a major factor shaping coding-sequence evolution; we continue to test and elaborate on this hypothesis. My group has also found a universal trend of selection for efficient translation initiation in a broad survey of over 300 species, including bacteria, archaea, and eukaryotes.
2. I develop mathematical or simulation models that predict aspects of microbial adaptation, such as the expected increase in fitness over time. These models provide valuable insight to the growing number of experimentalists who carry out laboratory evolution experiments with microbes.
3. My research interests of molecular evolution and microbial adaptation have important applications for infectious diseases. My group is studying both specific disease systems, such as HIV, and broader questions, such as how viral sequence data relate to epidemiological quantities such as disease prevalence or incidence.
For a complete list of publications and links to articles, see here.
- C. O. Wilke and D. Allan Drummond. Population genetics of translational robustness. Genetics 173:473-481.
D. A. Drummond, A. Raval, and C. O. Wilke. A Single Determinant Dominates the Rate of Yeast Protein Evolution Mol. Biol. Evol. 23:327-337, 2006.
- C. O. Wilke, R. Forster, and I. S. Novella. Quasispecies in time-dependent environments. Curr. Topics Microbiol. Immun. 299:33-50, 2006.
- R. Forster and C. O. Wilke. Tradeoff between short-term and long-term adaptation in a changing environment. Phys. Rev. E 72:041922, 2005.
- C. O. Wilke, J. D. Bloom, D. A. Drummond, and A. Raval. Predicting the tolerance of proteins to random amino acid substitution. Biophys. J. 89:3714-3720, 2005.
- D. A. Drummond, J. D. Bloom, C. Adami, C. O. Wilke, and F. H. Arnold. Why highly expressed proteins evolve slowly. Proc. Natl. Acad. Sci. USA 102:14338-14343, 2005.
- C. O. Wilke. Quasispecies theory in the context of population genetics. BMC Evol. Biol. 5:44, 2005.
- C. O. Wilke. The heavy, the cold and the slow. Heredity 95:115, 2005.
- D. A. Drummond, J. J. Silberg, M. M. Meyer, C. O. Wilke, and F. H. Arnold. On the conservative nature of intragenic recombination. Proc. Natl. Acad. Sci. USA 102:5380-5385, 2005.
- J. D. Bloom, J. J. Silberg, C. O. Wilke, D. A. Drummond, C. Adami, and F. H. Arnold. Thermodynamic prediction of protein neutrality. Proc. Natl. Acad. Sci. USA 102:606-611, 2005.
- C. Ofria and C. O. Wilke. Avida: Evolution experiments with self-replicating computer programs. In A. Adamatzky and M. Komosinski, eds. Artificial Life Models in Software. Springer, 2005, pp. 3-36.
- C. O. Wilke and S. S. Chow. Exploring the evolution of ecosystems with digital organisms. In M. Pascual and J. Dunne, eds. Ecological Networks. Linking Structure to Dynamics in Food Webs. Oxford University Press, 2005.
- C. O. Wilke. Molecular clock in neutral protein evolution. BMC Genetics 5:25, 2004.
- C. O. Wilke. Supplementary materials need the right format. Nature 430:291, 2004.
- S. S. Chow*, C. O. Wilke*, C. Ofria, R. E. Lenski, and C. Adami. Adaptive Radiation from Resource Competition in Digital Organisms. Science 305:84-86, 2004. *Joint first authorship.