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Paul M Macdonald
Paul Macdonald

Professor
Mr. and Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology

Ph.D. Vanderbilt University, 1983

pmacdonald@mail.utexas.edu

Office MBB 2.422
(512) 232-6292

Macdonald Lab home page

Video PC Mac  

We use the fruit fly, Drosophila melanogaster, to learn how patterning determinants -- molecules that program embryonic body patterning -- are deployed at specific sites in the egg or embryo.
We know of three basic mechanisms involved in deployment of the determinants: mRNA localization, translational regulation, and protein anchoring. Most of our work involves the first two mechanisms.


Selected Publications



Macdonald, P.M. Diversity in translational regulation. (2001) Current Opinion in Cell Biology 13, 326-331.

Mancebo, R., Zhou, X., Shillinglaw, W., Henzel, W. and Macdonald, P.M. (2001) BSF binds specifically to the bicoid mRNA and contributes to its stabilization. Molecular and Cellular Biology 21, 3462-3471.

Harris, A.N. and Macdonald, P.M. (2001) aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128, 2823-2832.

Arn, E.A. and Macdonald, P.M. (2001) RNA localization goes direct. Direct injection of RNA provides a new view of localization during Drosophila oogenesis. Developmental Cell 1, 155-156.

Arn, E.A., Cha, B.J., Theurkauf, W.E. and Macdonald, P.M. (2003) Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod and RNA binding proteins. Developmental Cell 4, 41-51.

Snee, M.J. and Macdonald, P.M. (2004) Live imaging of nuage and polar granules: evidence against a precursor-product relationship, and a novel role for Oskar in stabilization of polar granule components. Journal of Cell Science 117, 2109-2120.

Macdonald, P.M. (2004) Translational Regulation: A Cup Half Full. Current Biology 14, R282-R283.

Braat, A.K., Yan, N., Arn, E., Harrison, D. and Macdonald, P.M. (2004) Localization-dependent Oskar protein accumulation: control after the initiation of translation. Developmental Cell 7, 125-131.

Yan, N. and Macdonald, P.M. (2004) Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta. Genetics 168, 1433-1442.

Snee, M.J., Arn, E.A., Bullock, S.L. and Macdonald, P.M. (2005) Recognition of the bcd mRNA localization signal in Drosophila embryos and ovaries. Molecular and Cellular Biology 25, 1501-1510.

Macdonald, P.M. (2005) Translational repression by Bicoid: competition for the cap. Cell 121, 321-322.

Burgler, C. and Macdonald, P.M. (2005) Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. BMC Genomics 6, 88.

Geng, Y. and Macdonald, P.M. (2006) Imp associates with Squid and Hrp48 and contributes to localized expression of gurken . Molecular and Cellular Biology 26, 9508-9516.

Snee, M.J., Harrison, D., Yan, N. and Macdonald, P.M. (2007) A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno. Differentiation, in press.

Jones, J.R. and Macdonald, P.M. (2007) Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Development 134, 233-236.

 
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