John Wallingford

John Wallingford

	Assistant Professor Ph.D. University of Texas at Austin, 1998 wallingford@mail.utexas.edu Office PAT 222 (512) 232-2784 Wallingford Lab home page


Molecular and cellular basis of embryonic morphogenesis. The process by which embryos acquire their final shape involves the coordination of cell fate decisions with cell movement. We are taking an integrated approach to understanding this process in vertebrate embryos. We combine molecular manipulations, time-lapse imaging, and old-fashioned cut & paste embryology to investigate molecular signaling, individual cell behavior, and tissue rearrangement. By considering all of these components and how they affect the final body plan, we hope to build a comprehensive picture of early embryonic morphogenesis. Currently, we are focused on mechanisms underlying neural tube closure and gastrulation.

Selected Publications Park, T.J., Haigo, S.L., and Wallingford, J.B. 2006. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nature Genetics 38, 303-311. Park, T.J., Gray, R.S., Sato, A., Habas, R., and Wallingford, J.B. 2005. Subcellular localization and signaling properties of Dishevelled in developing vertebrate embryos. Current Biology 15, 1039-1044. Ewald, A.J., Peyrot, S.M., Tyszka, J.M., Fraser, S.E. and Wallingford, J.B. 2004. Regional requirements for Dishevelled signaling during Xenopus gastrulation: Separable effects on blastopore closure, mesendoderm internalization, and archenteron formation. Development 131, 6195-6209. Haigo, S.L., Hildebrand, J.D., Harland, R.M., and Wallingford, J.B. 2003. Shroom induces apical constriction and is required for hingepoint formation during neural tube closure. Current Biology 13, 2125-2137.

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