Research Lab Members:
Patterson, Kristin
Research Summary:
My laboratory uses Drosophila genetics and molecular biology to study universal mechanisms of development. We do most of our experiments with the Drosophila compound eye. Patterning of the Drosophila compound eye involves nearly every known cell signaling pathway and the eye affords many experimental advantages. We are studying how the Notch signaling pathway is regulated by membrane trafficking and ubiquitination.
Research Images:
Janice Fischer -
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Publications:
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2012
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Lee J-H, Fishcer JA,
Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling.,
PLoS ONE
7(9):
e46357
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2012
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Cho B, Fischer JA,
Ral inhibits ligand-independent Notch signaling in Drosophila.,
Small GTPases
3(3):
186-191
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2012
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Xie X, Cho B, Fischer JA,
Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.,
Developmental Biology
363(2):
399-412
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2011
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Weinmaster G, Fischer JA ,
Notch ligand ubiquitylation: what is it good for? ,
Developmental Cell
21:
134-144
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2011
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Banks SML, Cho B, Eun SH, Lee J-H, Windler SL, Xie X, Bilder D, Fischer JA ,
The Functions of Auxilin and Rab11 in Drosophila Suggest that the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells is Not Recycling.,
PLoS ONE
6(3):
e18259
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2011
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Cho B, Fischer JA,
Ral GTPase promotes asymmetric Notch activation in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. ,
Development
138:
1349-1359
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2009
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Lee J-H, Overstreet E, Fitch E, Fleenor, Fischer JA ,
Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. ,
Developmental Biology
331:
1-13
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2008
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Wu Y, Bolduc FV, Bell K, Tully T, Fang Y, Sehgal A, Fischer JA,
A Drosophila model for Angelman syndrome,
Proceedings of the National Academy of Sciences, USA
105:
12399-12404
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2008
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Eun SH, Banks S, Fischer JA ,
Auxilin is essential for Delta signaling,
Development
135:
1089-1095
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2007
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Eun SH, Lea K, Overstreet E, Stevens S, Lee J-H, Fischer JA,
Identification of genes that interact with Drosophila liquid facets,
Genetics
175:
1163-1174
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2006
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Fischer JA, Eun SH, Doolan BT,
Endocytosis, endosome trafficking and the regulation of Drosophila development,
Annual Review of Cell and Developmental Biology
22:
181-206
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2004
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Overstreet E, Fitch E, Fischer JA ,
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells,
Development
131:
5355-5366
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2003
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Overstreet E, Chen X, Wendland B, Fischer JA ,
Either part of a Drosophila epsin (Liquid facets) protein, divided after the ENTH domain, functions in the internalization of Delta in the developing eye,
Current Biology
13:
854-860
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2002
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Chen X, Zhang B, Fischer, JA ,
A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Faf facets,
Genes and Development
16:
289-294
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