Research Lab Members:
Lovely, Charles
McCarthy, Neil
McGurk, Patrick
Rozacky, Jenna
Swartz, Mary
Research Summary:
How does a structure as complex as the vertebrate head form during development? How is variation in facial morphology generated both through evolution and in disease? Research in my lab aims at uncovering answers to these questions, primarily using the zebrafish as a model organism. Using live imaging of developing transgenic embryos we can analyze the cell movements and interactions that drive morphogenesis. We also employ genetics, molecular biology and classic embryology to dissect the regulatory networks underlying facial development. Our goal is to build a comprehensive understanding of the genetic and environmental inputs underlying facial morphogenesis.
Research Images:
Publications:
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2013
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Eberhart J.K. and Harris R.A.,
Understanding variability in ethanol teratogenicity,
PNAS
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2012
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M.E. Swartz, V. Nguyen, N.Q. McCarthy and J.K. Eberhart,
Hh signaling regulates patterning and morphogenesis of the pharyngeal arch-derived skeleton,
Dev Biol.
369:
65-75
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2011
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Swartz ME, Sheehan-Rooney K, Dixon MJ, Eberhart JK.,
Examination of a palatogenic gene program in zebrafish.,
Dev Dyn.
240:
2204-20.
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2011
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He X, Yan YL, Eberhart JK, Herpin A, Wagner TU, Schartl M, Postlethwait JH.,
miR-196 regulates axial patterning and pectoral appendage initiation.,
Dev Biol.
357:
463-77
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2011
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Sheehan-Rooney K, Pálinkášová B, Eberhart JK, Dixon MJ.,
A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages.,
Dev Dyn.
239:
3481-91
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2011
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Tittle RK, Sze R, Ng A, Nuckels RJ, Swartz ME, Anderson RM, Bosch J, Stainier DY, Eberhart JK, Gross JM.,
Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens.,
Dev Biol.
350:
50-63
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2009
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X. He, J.K.Eberhart and J.H. Postlethwait,
MicroRNAs and micromanaging the skeleton in disease, development and evolution,
J. Cell Mol. Med.
13:
606-618
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2008
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Kimmel CB, Eberhart JK.,
The midline, oral ectoderm, and the arch-0 problem.,
Integr Comp Biol.
48:
668-80
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2008
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J.K. Eberhart, X. He, M.E. Swartz, Y-L. Yan, H. Song, T. Boling, A.K. Kunerth, M.B. Walker, C.B. Kimmel, and J.H. Postlethwait ,
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis,
Nat. Genet.
40:
290-298
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2007
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M.B. Walker, C.T. Miller, M.E. Swartz, J.K. Eberhart and C.B. Kimmel,
Phospholipase c, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish,
Dev. Biol.
304:
194-207
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2007
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M.R. Miller, T.S. Atwood, B.F. Eames, J.K. Eberhart, Y.L. Yan, J.H. Postlethwait and E.A. Johnson ,
RAD marker microarrays enable rapid mapping of zebrafish mutations,
Genome Biol.
8:
R105
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2007
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C.T. Miller, M.E. Swartz, P.A. Khuu, M.B. Walker, J.K. Eberhart and C.B. Kimmel ,
mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish,
Dev. Biol.
308:
144-157
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2006
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J.K. Eberhart, M.E. Swartz, J.G. Crump and C.B. Kimmel,
Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development,
Development
133:
1069-1077
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2006
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J.G. Crump, M.E. Swartz, J.K. Eberhart and C.B. Kimmel,
Moz-dependent hox expression controls segment-specific of skeletal precursors in the face,
Development
133:
2661-2669
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2005
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Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME.,
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.,
Neuron
46:
191-204
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2004
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Eberhart J, Barr J, O'Connell S, Flagg A, Swartz ME, Cramer KS, Tosney KW, Pasquale EB, Krull CE.,
Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons.,
J Neurosci.
24:
1070-8
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2002
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Eberhart J, Swartz ME, Koblar SA, Pasquale EB, Krull CE.,
EphA4 constitutes a population-specific guidance cue for motor neurons.,
Dev Biol.
247:
89-101
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2001
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Swartz M, Eberhart J, Mastick GS, Krull CE.,
Sparking new frontiers: using in vivo electroporation for genetic manipulations.,
Dev Biol.
233:
13-21
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2001
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Swartz ME, Eberhart J, Pasquale EB, Krull CE.,
EphA4/ephrin-A5 interactions in muscle precursor cell migration in the avian forelimb.,
Development
128:
4669-80
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2000
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Eberhart J, Swartz M, Koblar SA, Pasquale EB, Tanaka H, Krull CE.,
Expression of EphA4, ephrin-A2 and ephrin-A5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding.,
Dev Neurosci.
22:
237-50
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