Bob G. Sanders
Dr. Sanders' research interests are in the interdisciplinary areas of cancer biology, immunology, and biological response modification. Studies are currently focused on investigating the role of vitamin E compounds as biological response modifiers of cancer cell growth and survival. Cellular and molecular mechanisms of action of vitamin E compounds as tumor cell growth regulators and immunomodulators are under study.
Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, V. Knight, B. E. Gilbert, C. Conti, B. G. Sanders, and K. Kline. 2003. "Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis." Molecular Cancer Therapeutics. 2: 437-444.
Yu, W., B. G. Sanders and K. Kline. 2003. "RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria." Cancer Research. 63: 2483-2491.
Yu, W., B. G. Sanders and K. Kline. 2002. "RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta independent activation of p21 (Waf1/Cip1)." Nutrition and Cancer. 43: 227-236.
You, H., W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders, and K. Kline. 2002. "Role of extracellular signal-regulated kinase pathway in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells." Molecular Carcinogenesis. 4: 228-236.
You, H., W. Yu, B. G. Sanders, and K. Kline. 2001. "RRR-alpha-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation." Cell Growth & Differentiation. 12: 471-480.
Yu, W., Q. Y. Liao, F. M. Hantash, B. G. Sanders, and K. Kline. 2001. "Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells." Cancer Research. 61: 6569-6576.
Kline, K., W. Yu, and B. G. Sanders. 2001. "Vitamin E: Mechanisms of action as tumor cell growth inhibitors." Journal of Nutrition. 131: 161S-163S.
Israel, K., W. Yu, B. G. Sanders, and K. Kline. 2000. "Vitamin E succinate (VES) induces apoptosis in human prostate cancer cells: Role for Fas in VES-triggered apoptosis." Nutrition and Cancer. 36: 90-100.
Yu, W., K. Israel, Q. Y. Liao, M. Aldaz, B. G. Sanders, and K. Kline. 1999. "Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: Role of Mr 43,000 Fas in VES-triggered apoptosis." Cancer Research. 59: 953-961.
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