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Faculty
Adron Harris
M. June and J. Virgil Waggoner Chair In Molecular Biology
Director, Waggoner Center for Alcohol & Addiction Research
Email:
harris@austin.utexas.edu
Website
Main Office:
MBB 1.124
Phone:
232-2514
Alternate Office:
ARC 2.124
Alt. Phone:
471-2106
Mailing Address
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway, MBB 1.124
Austin ,TX 78712-1095
Research Summary
This laboratory is investigating molecular mechanisms responsible for alcoholism and drug dependence. We are defining actions of alcohol and other drugs on brain cells as well as the long-term changes in gene expression responsible for tolerance and dependence. The ion channels controlling neuronal excitability are of particular importance in our studies. Another aspect is the neurochemical basis for genetic differences in drug response. These experiments use genetically modified mice that vary in susceptibility to drug intoxication and dependence. A student working in this laboratory would carry out some of the following studies: (a) effects of drugs on ion channels; (b) site-directed mutagenesis of ion channels; (c) functional and structural studies of brain neurotransmitter receptors; (d) gene expression profiles of humans and mice using cDNA microarrays.
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