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Faculty
Robert Krug
Chair, Molecular Genetics and Microbiology,
Lorene Morrow Kelley Fellow In Microbiology

Email: rkrug@mail.utexas.edu
Website
Main Office: MBB 2.122BA
Phone: (512) 232-5563

Alternate Office: MBB 2.122
Alt. Phone: (512) 232-5566

Mailing Address
The University of Texas at Austin
Section of Molecular Genetics and Microbiology
2500 Speedway Stop A4800
Austin ,TX 78712-1191
Robert Krug

Research Summary

The major focus of the Krug laboratory is the molecular biology of human influenza viruses (influenza A and B viruses), which cause widespread human disease. We are determining the molecular mechanisms of viral mRNA synthesis and viral RNA replication; and how the viral nonstructural proteins of these two influenza viruses contribute to pathogenesis and overcome host defense by inhibiting crucial cellular functions, including the 3-prime end processing system used for the production of cellular pre-mRNAs, and the interferon-induced modification of proteins by the ISG15 ubiquitin-like protein. Our research has already identified promising new targets for the development of antivirals, which are now the subject of high-throughput screens. In addition, research on influenza A viruses includes the analysis of the functions of the genes of H5N1 avian influenza viruses, which have the potential for causing the next pandemic.