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Faculty
Michael Mauk
Professor of Neurobiology
Email:
mmauk@mail.clm.utexas.edu
Website
Main Office:
NHB 3.342
Phone:
512-232-3978
Alternate Office:
NHB 3.310
Alt. Phone:
512-232-0890
Mailing Address
University of Texas at Austin
1 University Station C7000
NMS 4.104
Austin ,TX 78712-0805
Research Summary
We investigate information processing and learning in the cerebellum and prefrontal cortex. The levels of analysis are: 1) behavioral studies, reversible lesions and in vivo recordings of neural activity related to eyelid conditioning in the rabbit, 2) large-scale computer simulations of the cerebellum. Eyelid conditioning: The cerebellum contributes to our ability to make accurate movements through experience (motor learning). We study a tractable example of motor learning -- delay eyelid conditioning in rabbits and mice -- to study the mechanisms of this learning. We also use trace eyelid conditioning in rabbits to study learning in prefrontal cortex and to study interactions between prefrontal cortex and cerebellum. Computer simulations: The cerebellum is especially amenable to analysis using computer simulations, due to the relatively simple way it is engaged by motor learning and to it�s well known and simple synaptic organization. We use large-scale simulations designed to reflect as accurately as possible key properties of the cerebellum to 1) test hypotheses regarding network properties of the cerebellum, 2) identify key experiments, and 3) as an overall index of our understanding of cerebellar mechanisms of motor learning.
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