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Shelley Payne

Payne, Shelley
Professor of Molecular Genetics & Microbiology
University Distinguished Teaching Professor

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Main Office: NMS 2.124 Phone: 471-9258

Alternate Office: NMS 2.246 Phone: 471-5204

Mailing Address:
The University of Texas at Austin, Mol. Gen. and Microbiol.
1 University Station A5000
100 E. 24th St.
Austin,TX 78712-1095

Research Lab Members:
  • Coughlin, Laura
  • Fisher, Carolyn
  • Gore, Aja
  • Helton, Emily
  • Ma, Li
  • Marman, Hannah
  • Mey, Alexandra
  • Wyckoff, Elizabeth

    • Research Summary:
    We are interested in the genetics and regulation of virulence factors of gram negative pathogens, including Shigella and Vibrio cholerae. Members of the Shigella species are found both extracellularly and intracellularly within the host, and distinct sets of genes are expressed in each of these environments. We are studying bacterial gene expression in vivo by a variety of molecular and microscopic techniques, and we have identified genes that are required for growth in the intracellular environment of the host. Bacterial genes found to be important for growth and survival in vivo include those that encode components of iron transport systems and those required for expression and localization of cell surface proteins.


    Publications:
    2009 Fisher CR, Davies NM, Wyckoff EE, Feng Z, Oaks EV, Payne SM, Genetics and virulence association of the Shigella flexneri sit iron transport system, Infect. Immun. 77: 1992-1999
    2009 Wyckoff EE, Boulette ML, Payne SM, Genetics and environmental regulation of Shigella iron transport systems, Biometals 22: 43-51
    2009 Be'er A, Zhang HP, Florin EL, Payne SM, Ben-Jacob E, Swinney HL, Deadly competition between sibling bacterial colonies, Proc Natl Acad Sci U S A 106: 428-433
    2008 Mey AR, Wyckoff EE, Hoover LA, Fisher CR, Payne SM, Vibrio cholerae VciB promotes iron uptake via ferrous iron transporters, J. Bacteriology 190: 5953-5962
    2007 Boulette, M.L. and S.M. Payne, Anaerobic regulation of Shigella flexneri virulence:ArcA regulates fur and iron acquisition genes, J. Bacteriology 189: 6957-6967
    2007 Wyckoff, E.E., A.R. Mey and S.M. Payne, iron acquisition in Vibrio cholerae, Biometals 20: 405-416
    2007 Kresse A. U., I. Reinacker, A.M. Valle, H. Steinruck, H. Claus, S.M. Payne, H. Tschape, P.H. Williams, R. Reissbrodt, Enterohaemorrhagic Escherichia coli O157 and non- 0157 serovars differ in their mechanisms for iron supply, Int. J. Med. Microbiol. 297: 9-158
    2007 Bhadra, S., M. Lozano, S. M. Payne, and J. P. Dudley, A Unique Mechanism of Resistance to Viral and Bacterial Pathogens, PLoS Pathogens 2: e128
    2007 Murphy, E.R. and S. M. Payne, RyhB, an iron-responsive small RNA, regulates Shigella virulence , Infect. immun. 75: 3470-3477
    2007 Purdy, G., C. Fisher and S. M. Payne, IcsA surface presentation in S. flexneri requires the periplasmic chaperones DegP, Skp and SurA, J. Bacteriol. 189: 5566-5573
    2006 Wycoff, E.E., A.R. Mey, A. Leimbach, C.F. Fisher and S.M. Payne, Characterization of ferric and ferrous iron transport systems in Vibrio Cholerae, J. Bact. 188: 6515-6523
    2006 Sharma, A.K. and S. M. Payne, Induction of expression of hfq by DksA is essential for Shigella flexneri virulence, Mol. MIcrobiol. 62: 463-479
    2005 Runyen-Janecky L.J., A. M. Boyle, A. Kizzee, L. Liefer, S. M. Payne, Role of the Pst system in plaque formation by the intracellular pathogen Shigella flexneri, Infect. Immun. 73: 1404-1410
    2005 Mey, A. R., E. E. Wyckoff, V. Kanukurthy, C. R. Fisher and S. M. Payne, Iron and Fur regulation in Vibrio cholerae and the role of Fur in virulence, Infect. Immun. 73: 8167-8178
    2005 Oglesby, A. G., E. R. Murphy, V. R. Iyer, and S. M. Payne, Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP, Mol. Microbiol. 58: 1354-1367
    2005 Mey, A. R., S. A. Craig, and S. M. Payne, Characterization of V. cholerae RyhB: the RyhB regulon and the role of ryhB in biofilm formation, Infect. Immun. 73: 5706-5719
    2004 Wyckoff, E.E., M. Schmitt, A., Wilks, S.M. Payne, HutZ is required for efficient heme utilization in Vibrio cholerae, J. Bacteriol. 186: 4142-4151
    2003 Wei, J., et al., Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T, Infect. Immun. 71: 2775-2786
    2003 Mey, A.R. and S.M. Payne, Analysis of residues determining specificity of V. cholerae TonB1 for its receptors, J. Bacteriol. 185: 1195-1207
    2003 Runyen-Janecky, L.S. Reeves, E. Gonzales, and S.M. Payne, Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cells, Infect. Immun. 71: 1919-1928