Core Classes
BIO 393 Microbial Genetics and Physiology (Fall)  This course on microbial genomics will cover prokaryotic and lower eukaryote genome organization; control of gene/operon/regulon expression; chromosome replication and its control; signal transduction; protein trafficking; organelle assembly; the cell cycle and its control; developmental processes; cell-cell communication; and DNA polymorphisms and adaptation.   The model organisms will include Escherichia coli, Bacillus subtilis,  Caulobacter crescentus, Myxococcus xanthus, Neisseria gonorrhoeae, Salmonella, and
Saccharomyces cerevisiae

BIO 395F. Genetics (Fall) Basic principles of Mendelian and molecular genetics, and an exploration of the genetic toolbox using examples of analytic methods and modern manipulations. Focus on the genetic analysis of model organisms. Use of genetic tools in dissecting complex biological pathways, developmental processes and regulatory systems. Prerequisite: Graduate standing. An introductory course in genetics, such as Biology 325, is strongly recommended

BIO 395G. Biochemistry (Fall). Detailed consideration of the structure and function of proteins, with discussion of enzyme mechanisms and kinetics, the biochemistry of energy production, and the metabolism of lipids and nucleotides. Prerequisite: Graduate standing. A one-year undergraduate sequence in biochemistry, such as Chemistry 339K and 339L, is strongly recommended.

BIO 395H. Cell Biology (Spring)  Detailed consideration of mechanisms of growth control, cell regulation, mitosis, cell signaling, protein targeting, and the integration of these processes in various cellular processes. Prerequisite: Graduate standing; and Molecular Biology 395F and 395G, or consent of instructor.

BIO 395J. Molecular Biology (Spring). Detailed consideration of prokaryotic and eukaryotic mechanisms of DNA replication and transcription; post-transcriptional processing of transcription products; mechanism and regulation of the translation of messenger RNAs. Prerequisite: Graduate standing; and Molecular Biology 395F and 395G; or consent of instructor. 

Journal Clubs
Journal clubs for the Fall 2006  Journal Clubs for Spring 2007
(The following courses are offered at various times.  Please check course schedule for when they are being offered)

BIO 392. Bacterial Envelopes
BIO 392. Molecular Biology of Bacterial Pathogens
BIO 392. Biomolecular Machines
BIO 392. Fungal and Cell Molecular Biology
BIO 393. Ubiquitin conjugation pathways and the Proteasome
BIO 393. Ribonucleoproteins
BIO 393. Current Topics in Microbial Genetics
BIO 393. Molecular Cell Biology
BIO 393. Post-Transcriptional Gene Regulation
BIO 393. Developmental Genetics
BIO 383K. Aspects of Membrane Traffic
BIO 383K. Regulation of Cytokinesis
BIO 393. Eukaryotic Transcriptional Regulation
BIO 393. Control of Genome Interactions and Chromosome Dynamics
BIO 393. Molecular Biology of RNA

Other Microbiology Course Offerings
(The following courses are offered at various times.  Please check course schedule for when they are being offered)

 BIO 398T. Supervised Teaching Teaching under close supervision of course instructors for two semesters; weekly laboratory instruction of undergraduates in microbiology and/or general biology, group meetings with the instructor, individual consultations, and reports throughout the teaching period. Prerequisite: Graduate standing. 

BIO 391M. Tumor Biology Natural history and causal mechanisms of cancer; viral and chemical carcinogens. Prerequisite: Graduate standing, consent of instructor and the graduate adviser, and Biology 360K, or 330 and 130L. 

BIO 391P. Advanced Virology Replication of and transformation by DNA and RNA animal viruses.  Prerequisite: Graduate standing, consent of instructor and the graduate advser, and Biology 330. 

BIO 394M. Molecular Immunology Studies in cell signaling in the immune system, transgenic and knockout gene analysis, T and B cell selection and maturation, and development of the immune system.  Prerequisite: Graduate standing, and consent of instructor and the graduate adviser.

BIO 396. Membranes and Walls of Bacteria Structure, biosynthesis, and function of bacterial envelopes and walls, including associated optional components. Prerequisite: Graduate standing, a general microbiology course, and a biochemistry course.

BIO 397J. Advanced Genetics Intended mainly for first- and second-year graduate students. Selected related topics of current interest with an emphasis on molecular developmental genetics, and any needed review of classical genetics. Designed to help the student to read the literature critically, deliver a good seminar, and participate in thoughtful discussion. May not be counted toward the doctoral degree in microbiology. Prerequisite: Graduate standing, consent of instructor, and a course in genetics. 

BIO 393. Bacterial Signal Transduction Advance level studies in molecular and cellular biology of a wide variety of signal transduction systems in diverse microorganisms; the role of signal transduction across biological membranes in allowing cells to recognize and respond to their environment. Topics include chemotaxis and motility, morphogenesis and development, and secretion and virulence. Taught entirely through reading and discussion of original articles.  Meets with BIO 339M.  Prerequisite: Graduate standing, consent of instructor and the graduate advisor

BIO 394. Regulation of Eukaryotic Gene Expression Study of gene expression and its regulation in eukaryotes at the transcriptional and post-transcriptional levels. Includes transcription, RNA splicing, polyadenylation, RNA and RNA-protein interactions.  Meets with BIO 379J.  Prerequisite: Graduate standing and consent of graduate advisor.

Research and Dissertation Hours
(Progress is based on performance in research and work.  No classroom attendance.)

 BIO 182, 282, 382. Advanced Study and Research For each semester hour of credit earned, the equivalent of one class hour a week for one semester.  May be repeated for credit. Prerequisite: Graduate standing and consent of instructor and graduate adviser.

BIO 698A. Thesis The equivalent of three lecture hours a week for two semesters for Master's students. Offered on the letter-grade basis only. Prerequisite: graduate standing in microbiology and consent of the graduate adviser. 

BIO 698B. Thesis The equivalent of three lecture hours a week for two semesters for Master's students. Offered on the letter-grade basis only. Prerequisite: Microbiology 698A.

BIO 398R. Master's Report Preparation of a report to fulfill the requirement for the master's degree under the report option. The equivalent of three lecture hours a week for one semester. Offered on the letter-grade basis only.
Prerequisite: Graduate standing in microbiology and consent of the graduate adviser. 

BIO 399R, 699R, 999R. Dissertation Offered on the letter-grade basis only. Prerequisite: Admission to candidacy for the doctoral degree.

BIO 399W, 699W, 999W Dissertation Offered on the letter-grade basis only. Prerequisite: BIO 399R, 699R, or 999R.