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David  Crews

Crews, David
Ashbel Smith Professor of Integrative Biology, and Psychology

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Main Office: PAT 30 Phone: 512 471-1113

Alternate Office: PAT 34 Phone: 512 475-6738

Mailing Address:
The University of Texas at Austin
1 University Station C0930
2415 Speedway
Austin,TX 78712-1095


Research Lab Members:
  • Dias, Brian
  • Porter, Raymond
  • Ramsey, Mary
  • Sanderson, Nicholas
  • Shoemaker, Christina


  • Research Summary:
    One of my research programs focuses on sex determination as a case study in how evolution has produced very different mechanisms for achieving the same end. Here I take advantage of the fact that in many reptiles the sex of the offspring depends on the incubation temperature of the egg, a process known as temperature-dependent sex determination (TSD). One question concerns how the physical stimulus of temperature is transduced into a physiological stimulus that operates ultimately at a molecular level to determine an individual's gonadal sex. In this work I use the red-eared slider turtle as the animal model system. I have demonstrated that sex steroid hormones are the physiological equivalent of incubation temperature, serving as the proximate trigger for male and female sex determination. Temperature appears to accomplish this end by acting on genes coding for steroidogenic enzymes (e.g., steroidogenic factor 1 and aromatase) and sex steroid hormone receptors (e.g., estrogen and androgen receptors), and other transcription factors and signaling molecules (e.g., Sox9, Wnt4, FOXL2, Mis, and Pumilio). Phylogenetic analysis indicates that TSD is the precursor of sex determination by genotypic mechanisms (e.g., sex chromosomes). My other research focuses on epigenetics. There is now evidence that an individual's likelihood of developing health problems involves a combination of that individual's own exposures as well as exposures of ancestors in generations past. This transmission of life experiences across generations represents the newly emerging field of environmental epigenetics.



    Publications:
    2012 Crews D, Gillette R, Scarpino SV, Manikkam M, Savenkova MI, Skinner MK, Epigenetic transgenerational alterations to stress response in brain gene networks and behavior, PNAS 109: 9143-9148 view
    2011 Crews D, Gore AC., Life Imprints: Living in a Contaminated World., Environ Health Perspect 119: 1-3 view
    2008 Crews D., Epigenetics and its implications for behavioral neuroendocrinology., Front Neuroendocrinol 29 (3): 344-357 view
    2007 David Crews, Andrea C. Gore, Timothy S. Hsu, Nygerma L. Dangleben, Michael Spinetta, Timothy Schallert, Matthew D. Anway, and Michael K. Skinner, Transgenerational epigenetic imprints and mate preference., Proceedings of the National Academy of Sciences 104: 5942-5946