Research Summary:
The process by which embryos acquire their final shape involves the coordination of cell fate decisions with cell movement. We are taking an integrated approach to understanding
this process in vertebrate embryos. We combine molecular manipulations, time-lapse imaging, and old-fashioned cut & paste embryology to investigate molecular signaling, individual cell behavior, and tissue rearrangement. By considering all of these components and how they affect the final body plan, we hope to build a comprehensive picture of early embryonic morphogenesis.
Research Images:
Axolotl Neural plate -
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Xenopus Neural Plate -
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Xenopus neurula -
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Publications:
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2010
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Chung MI, Nascone-Yoder NM, Grover SA, Drysdale TA, Wallingford JB.,
Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut.,
Development
137:
1339-49
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2009
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Kieserman EK, Wallingford JB.,
In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.,
J Cell Sci
122:
2481-90
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2009
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Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH.,
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.,
Nat Cell Biol
11:
1225-35
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2008
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Park TJ, Mitchell BJ, Abitua PB, Kintner C, Wallingford JB.,
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.,
Nat. Genet.
40:
871-9
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2008
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Kieserman, E.K., Glotzer, M. and Wallingford, J.B.,
Developmental Regulation of Central Spindle Assembly and Cytokinesis during Vertebrate Embryogenesis,
Curr Biol
18:
116-123
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2007
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J.B. Wallingford and R.M. Harland,
Vertebrate gastrulation: the BMP sticker shock,
Curr Biol
17:
R206-9
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2007
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Hayes, J.M., Kim, S.K., Abitua, P.B., Park, T.J., Herrington, E,R., Kitayama, A, Grow, M.W., Ueno N. and Wallingford J.B.,
Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development,
Dev Biol
312:
115-130
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2007
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Lee, CJ., Scherr, H.M., and Wallingford, J.B.,
Shroom family proteins govern alpha-tubulin distribution and microtubule architecture during epithelial cell shape change. ,
Development
134:
1431-1441
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2006
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Fairbank, P.D., Lee, CJ., Ellis, A., Hildebrand, J.D., Gross, J.M., and Wallingford, J.B. ,
Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium. ,
Development
133:
4109-4118
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2006
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Park, T.J., Haigo, S.L., Wallingford, J.B.,
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling,
Nature Genetics
38:
303-311
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