Robert M. Krug
The major focus of the Krug laboratory is the regulation of the processing and nuclear export of cellular and viral mRNAs in virus-infected cells, and the structure and function of viral proteins that regulate this mRNA processing.
This research centers on the NS1 protein encoded by influenza A viruses (NS1A protein), which is a unique regulator of several cellular post-transcriptional events in both the nucleus and cytoplasm.
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein.Proc Natl Acad Sci U S A. 2004 May 18; 101(20): 7578-7582. published online before print May 6, 2004
EMBO J. 2003 Mar 3; 22(5): 1188-1198.
Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis.
Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: Outcome with influenza A virus is unique.Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15): 10096-10101. published online before print July 11, 2002
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits.EMBO J. 2001 Apr 17; 20(8): 2078-2086.
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.EMBO J. 2001 Feb 1; 20(3): 362-371.
Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein.Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9): 4864-4869.
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