Philip W. Tucker
| Title: | Marie Betzner Morrow Centennial Chair | 
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| Education: |
Ph.D.: 1974, Massachusetts Institute of Technology; M.A.: 1969, University of Texas; B.A.: 1966, University of Texas |
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| Postdoc.: | University of Wisconsin, Madison; MRC Laboratory of Molecular Biology, Cambridge, England; Roche Institute of Molecular Biology | |
| Research: | Molecular mechanisms controlling gene expression | |
| Office: | NMS 1.126 | |
| Phone: | (512) 475-7705 | |
| E-mail: | philtucker@mail.utexas.edu | |
| Postal Address: | The University of Texas at Austin
Molecular Genetics & Microbiology
1 University Station A5000
Austin TX 78712-0162 |
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| Courses taught: | BIO 393 "Problems in Molecular Genetics" BIO 595D "Molecular Biology II: DNA Replication and Gene Expression" |
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| Laboratory home page: http://www.bio.utexas.edu/research/tuckerlab/index.html | ||
We hope to better understand transcriptional regulation of lymphoid and cardiovascular development and function in normal and diseased mice and humans. Ongoing projects can be grouped operationally under four transcription factor families (ARID, BCL11, FOXp and SMYD) that we previously cloned and characterized. We employ a number of genomic, biochemical and genetic approaches to test how these factors work in isolated cells or in the intact animal. We want to know what goes wrong with them to promote leukemia or cardiac birth defects.
Niu, H., I.C., Maika, S.D., Tucker, P.W., and Gottlieb, P.D. (2005). A role for SATB1, a nuclear matrix association region (MAR) binding protein, in the development of CD8SP thymocytes and peripheral T lymphocytes. J. Immunol 174: 4745-4752.
Wang, B., Weidenfeld, J., Lu, M.M., Maika, S., Kuziel, W.A., Morrisey, E.E. and Tucker, P.W. (2004). FoxP1 regulates cardiac output tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development 131: 4477-4487.
Satterwhite, E., Sonoke, T., Willis, T.G., Siebert, R., Nowak, R., Arriola, E.L., Liu, H., Harder, L., Price, H.P., Gesk, S., Steinmann, D., Oscier, D.G., Schlegelberger, B., Dyer, M.J.S., and Tucker, P.W. (2001). The BCL11 gene family: Involvement of BCL11A in lymphoid malignancies. Blood 98:3413-3420.
Webb, C., Zong, R.-T., Lin, D., Wang, Z., Kaplan, M., Paulin, Y., Smith, E., Probst, L., Bryant, J., Goldstein, A., Scheuermann, R., and Tucker, P.W. (1999). Differential Regulation of Immunoglobulin Gene Transcription via Nuclear Matrix-associated Regions. Cold Spring Harbor Symps. Quant. Biol. 64: 109-118.
Kienker, L. J., M. R. Ghosh and P. W. Tucker.
Regulatory Elements in the Promoter of a Murine TCRD V Gene Segment.
J. Immunol.161 (1998): 791-804.
Wang, Z., A. Goldstein, R.-T. Zong, D. Lin, E. J. Neufeld, R. H. Scheruermann, and P. W. Tucker.
Cux/CDP Homeoprotein is a Component of NF-muNR and Represses the Immunoglobulin HEavy CHain Intronic Enhancer by Antagonizing the Bright Transcription Activator.
Mol. Cell. Biol. 19: 284-295.
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