Vishwanath (Vishy) Iyer
We are using genomic approaches for analyzing transcriptional programs and mechanisms in eukaryotic cells. One area of research involves the use of DNA microarrays to map the genome-wide, in vivo DNA binding distribution of a variety of transcription factors in yeast. Genes regulated by such transcription factors are identified by analyzing global changes in gene expression in response to modulation of the given factor. Another interest is the study of transcriptional control mechanisms in cellular proliferation and cancer biology. The expression of several transcription factors is altered during the transition of human cells from quiescence to proliferation. We are using human cDNA microarrays containing tens of thousands of human genes to identify genes involved in proliferation and to determine the downstream targets of oncogenic transcription factors.
Kim J., Bhinge A.A., Morgan X.C. & Iyer V.R. (2005) Mapping DNA-Protein Interactions in Large Genomes by Sequence Tag Analysis of Genomic Enrichment Nature Methods 2: 47-53. (Download PDF)
Iyer, V. R. (2004) Exploring the posttranscriptional RNA world with DNA microarrays Trends Biotechnol. 22: 498-500 (Download PDF)
Kim J. & Iyer V.R. (2004) Global role of TATA-box binding protein recruitment to promoters in mediating gene expression profiles Mol. Cell. Biol. 24: 8104-8112 (Download PDF)
Hahn, J.S., Hu Z., Thiele D. J.* and Iyer V.R.* (2004) Genome-Wide Analysis of the Biology of Stress Responses through Heat Shock Transcription Factor. Mol. Cell. Biol. 24: 5249-5256 (Download PDF)
Killion P. J., Sherlock G. & Iyer V. R. (2003) The Longhorn Array Database (LAD): An Open-Source, MIAME compliant implementation of the Stanford Microarray Database (SMD) BMC Bioinformatics 4:32 (Download PDF)
Pollack J. R. & Iyer V.R. (2002) Characterizing the physical genome. Nature Genetics 32 suppl: 515-521 (Download PDF)
Iyer V. R., Horak C., Scafe C. S., Botstein D., Snyder M. & Brown P. O. (2001) Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF.
Sudarsanam P., Iyer V. R., Brown P. O. & Winston F. (2000) Whole-genome expression analysis of snf/swi mutants of S. cerevisiae.
DeRisi J. L. & Iyer V. R. (1999) Genomics and array technology.
Iyer V. R., Eisen M. B., Ross D. T., Schuler G., Moore T., Lee J. C.,F., Trent J. M., Staudt L. M., Hudson Jr. J., Boguski M. S., Lashkari D., Shalon D., Botstein D. & Brown P. O. (1999) The transcriptional program in the response of human fibroblasts to serum.
DeRisi J. L., Iyer V. R. & Brown P. O. (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale.
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