The College of Natural Sciences at The University of Texas at Austin
The University of Texas at Austin

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Vishwanath Iyer
Professor in Molecular Genetics & Microbiology

Main Office: MBB 3.212AA
Phone: (512) 232-7833

Alternate Office: MBB 3.212
Alt. Phone: (512) 232-7834

Mailing Address
The University of Texas at Austin
Institute for Cellular and Molecular Biology
2500 Speedway Stop A4800
Austin ,TX 78712-1191

Vishwanath Iyer

Research Summary

Nearly all cells respond to physiological or developmental cues by large-scale transcriptional reprogramming – altering the expression of hundreds to thousands of genes throughout the genome. Such sweeping changes in gene expression also underlie diseases such as cancer, and they can also be caused by normal or abnormal genetic variation between individuals. Our lab is interested in understanding how gene expression is regulated across a eukaryotic genome. We focus on regulation not only at the level of transcription, but also post-transcriptional regulation mediated by miRNAs. We work in human cells and also use yeast as a model system to address various questions regarding global gene regulation. We use molecular and genomic experimental methods such as microarrays and next-generation sequencing, coupled with computational analyses. Broad research areas in the lab include i) transcriptional regulatory networks in yeast during stress responses, ii) role of chromatin structure and remodeling in transcriptional regulation, iii) regulatory networks during human cell proliferation, iv) regulation and function of miRNAs during proliferation, v) relationship of transcription regulation with genetic variability among individuals.



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