The College of Natural Sciences at The University of Texas at Austin
The University of Texas at Austin

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S. John Mihic
M. June and J. Virgil Waggoner Fellow In Molecular Biology
Associate Professor

Main Office: MBB 1.148BA
Phone: 232-7174

Alternate Office: MBB 1.148
Alt. Phone: 232-7173

Mailing Address
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway
Austin ,TX 78712-1095

S. John Mihic

Research Summary

Research in my laboratory is focused on characterizing the molecular mechanisms of action of alcohol, inhaled solvents and anaesthetics on ligand-gated ion channels. We combine receptor subunit mutagenesis with electrophysiological characterization of receptors expressed by either cultured cells or Xenopus oocytes. Our studies are carried out using both whole-cell and single-channel electrophysiological recordings. We have identified specific amino acids of these receptors responsible for alcohol and volatile anaesthetic enhancement of GABA-A and glycine receptor function. Currently the lab is continuing the characterization of alcohol and anaesthetic actions on these receptors using single channel recording techniques. We are also using phage display to identify novel peptide modulators of ion channels. A second major research interest is the elucidation of the basic mechanisms of ion channel opening and receptor desensitization.



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