Professor in Molecular Genetics & Microbiology
Main Office: NMS 1.110
Phone: (512) 471-1692
Alternate Office: NMS 1.202
Alt. Phone: (512) 471-0931
The University of Texas at Austin
Molecular Biosciences, College of Natural Sciences
2506 Speedway Stop A5000
Austin ,TX 78712-1191
My research interests include the mechanism by which the bacterial chromosome is replicated, how replication is controlled, and how replication is integrated with cell division. Specifically, we study components of the Escherichia
coli replicative polymerase, DNA polymerase III, the specific functions of some of the subunits of this ten-protein complex, and how the genes which encode these subunits are expressed and regulated. Also under study is the mechanism by which a critical activator protein initiates replication at the unique replication origin once and only once in each cell cycle and always at the same time in the cell cycle. E. coli was chosen as a model for replication in higher organisms because the mechanisms are thought to be very similar, but work with E coli provides the advantage of superior technology and genetic analysis.
We are interested also in the structure and developmental
biology of long, ribbon-like appendages attached to Clostridium spores.