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Faculty
Boris Zemelman
Assistant Professor of Neuroscience

Email: zemelmanb@mail.clm.utexas.edu
Main Office: NHB 3.116
Phone: 512-232-6364

Alternate Office: NHB 3.120
Alt. Phone: 512-232-5796

Mailing Address
The University of Texas at Austin
1 University Sta Stop C7000
NHB 2.504
Austin ,TX 78712-0805

Boris Zemelman


Research Summary

We strive to understand the role of hippocampus in memory formation by manipulating its functional elements, namely the assemblies of cells that carry out particular tasks. This objective raises four practical questions. How are such assemblies to be defined? How can they be accessed? How might their activity be perturbed? And how should the resulting change in the system be detected and evaluated? Hippocampal neurons are organized into three broad classes: excitatory, inhibitory and modulatory. In some cases, the classes can be subdivided further, on the basis of neurochemical markers, mainly calcium binding proteins and neuropeptides. We work in mice, using these differences in the complement of expressed proteins to target specific cell populations. As an alternative, we are developing novel genetic approaches designed to identify and access neurons displaying heightened activity during memory tasks. Selected neurons are sensitized to subsequent manipulation using a variety of heterologous receptors and ion channels. We then evaluate the effects of cell-type specific optical or pharmacological perturbations on hippocampal circuit dynamics (electrophysiologically) and on animals’ memory functions (using behavioral assays).

 

 

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