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Bryan W Davies

Davies, Bryan W
Assistant Professor in Molecular Genetics and Microbiology

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The University of Texas at Austin
Section of Molecular Genetics & Microbiology
2506 Speedway Stop A5000
Austin,TX 78712-1191


Introduction:
Bryan earned his bachelors degree in Biochemistry at McMaster University and Ph.D. in Molecular Biology at the Massachusetts Institute of Technology (MIT).



Research Summary:
Bryan started January 16, 2013 in the section of Molecular Genetics and Microbiology. His graduate research explored many areas including responses to DNA damage, ribosome maturation and plant/bacteria symbiosis. During his postdoctoral fellowship at Harvard Medical School Bryan fused traditional genetics with functional genomics and mass spectrometry to decipher virulence gene regulation in the bacterial pathogen Vibrio cholerae. While continuing his research on gene networks required for V. cholerae virulence, Bryan has expanded his investigations to the environmental persistence of hospital pathogens. This latter project aims to understand how certain bacteria can thrive in the hospital setting and how cleaning practices can be improved to help slow the transmission of antibiotic resistant bacteria to and between patients.



Publications:
2011 Davies, B. W., Bogard, R. W., Dupes, N. M., Gerstenfeld, T. A. I., Simmons, L. A. and Mekalanos, J. J., DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine., PLoS Pathog 7(2): e1001295
2011 Davies, B. W., Bogard, R. W. and Mekalanos, J. J., Mapping of Vibrio cholerae Fur Regulon Identifies Unique Roles in sRNA and Transport Regulation., PNAS 180(30): 12467-72
2011 Davies, B. W., Bogard, R. W., Young, T. S. and Mekalanos J. J., Regulatory crosstalk between accessory genetic elements produces cyclic di-nucleotides required for Vibrio cholerae virulence., Cell
2010 Davies, B. W., Koehrer, C., Jacob, A. I., Simmons, L. A., Zhu, J., Aleman, L. M., Rajbhandary, U. L., and Walker, G. C., Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing., Mol. Microbiol 78(2): 506-518
2009 Simmons, L. A., Goranov, A. I., Kobayashi, H., Davies, B. W., Yuan, D. S., Grossman A. D. and Walker G. C., A comparison of response to double-strand breaks between Escherichia coli and Bacillus subtilis reveals different requirements for SOS induction., J. Bacteriology 191(4): 1152-61
2009 Davies, B. W., Kohanski, M. A., Simmons, L. A., Collins, J. J. and Walker G. C., Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli., Mol. Cell 36(5): 845-860
2007 Davies, B.W., and Walker, G.C., Identification of novel Sinorhizobium meliloti mutants compromised for oxidative stress protection and symbiosis., J. Bacteriol 189(5): 2110-2113
2007 Davies, B.W., and Walker, G.C., Disruption of sitA compromises Sinorhizobium meliloti for manganese-dependent oxidative stress protection., J. Bacteriol 189(5): 2101-2109
2007 Jones, K. M., Kobayashi, H., Davies, B. W., Taga, M. E. and Walker, G.C., Intracellular symbiosis by rhizobial bacteria: invasion and endocytosis., Nature Rev. Microbiol 5(8): 619-633
2001 McBurney, M.W., Lau, S., Jardine, K., Yang, X., and Davies, B., Reexpression of a cluster of silenced transgenes is associated with their rearrangement., Genes Chromosomes Cancer 32(4): 311-323.